Antioxidant supplements could help those with multiple sclerosis.
A review article published in the British Journal of Pharmacology assesses antioxidant approaches for treating neurodegenerative disorders such as multiple sclerosis, Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS).
The review, “Microglia antioxidant systems and redox signalling,” notes that certain compounds associated with oxidative stress appear to be promising therapeutic targets for treating neurodegenerative disorders, with researchers investigating the potential for enhancing antioxidant capacity by targeting what’s known as the Nrf2 pathway — a major regulator of antioxidant response.
The authors also note ongoing development of techniques to inhibit NADPH oxidases of the NOX family, which are key sources of reactive oxygen species (free radicals) that contribute to a wide range of pathological processes, potentially including immunosuppression and hypothyroidism. Increased NOX activity has also been found to contribute to a large number of other pathologies, particularly cardiovascular diseases and neurodegeneration.
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