Atezolizumab Plus Chemotherapy Approved for Initial Treatment of Extensive-Stage Small Cell Lung Cancer

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Atezolizumab Plus Chemotherapy Approved for Initial Treatment of Extensive-Stage Small Cell Lung Cancer

The Food and Drug Administration (FDA) has approved Tecentriq (atezolizumab; Genentech), in combination with carboplatin and etoposide, for the first-line treatment of adult patients with extensive-stage small cell lung cancer.

The Food and Drug Administration (FDA) has approved Tecentriq (atezolizumab; Genentech), in combination with carboplatin and etoposide, for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC).

The approval was based on data from the phase 3 IMpower133 study which evaluated the safety and efficacy of Tecentriq + chemotherapy vs chemotherapy alone in chemotherapy-naïve patients with ES-SLC (N=403). The co-primary efficacy outcomes of the study were overall survival (OS) and progression-free survival (PFS).

Results showed that patients treated with Tecentriq plus chemotherapy had significantly longer OS compared with those who received chemotherapy alone (12.3 vs 10.3 months; hazard ratio [HR] 0.70, 95% CI, 0.54–0.91; P=.0069). In addition, the combination therapy significantly reduced the risk of disease worsening or death (PFS 5.2 vs 4.3 months for chemotherapy alone; HR 0.77; 95% CI, 0.62–0.96; P=.017).

With regard to safety, the most common adverse reactions reported in ES-SCLC patients receiving Tecentriq plus chemotherapy were fatigue/asthenia, nausea, alopecia, decreased appetite, constipation, and vomiting. Serious adverse reactions occurred in 37% and 35% of patients treated with the combination therapy and monotherapy, respectively.

Read on: Atezolizumab Plus Chemotherapy Approved for Initial Treatment of Extensive-Stage Small Cell Lung Cancer

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