Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

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Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

Rheumatoid arthritis can also affect the strength of bones.

Bone strength is significantly reduced among men and women with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and is associated with the development of osteoporotic fractures, according to the results of a microfinite element analysis published in the Annals of the Rheumatic Diseases.

Investigators from the University of Erlangen-Nuremberg in Germany performed microfinite element analysis to measure failure load and bone stiffness based on computed tomography data from patients with ACPA-positive RA, patients with ACPA-negative RA, and healthy control participants. Total, trabecular, and cortical bone densities, along with microstructural parameters of bone, were also analyzed.

A total of 276 participants were evaluated. Failure load and stiffness of bone were both significantly decreased in patients with ACPA-positive RA (<.001), but not in those with ACPA-negative RA, compared with healthy control participants. Lower bone strength affected both men and women with ACPA-positive RA and was linked to longer disease duration and was significantly associated with the occurrence of osteoporotic fractures (stiffness of bone, P =.020; failure load, P =.012).

Impaired bone strength was linked to altered bone density and microstructural parameters, both of which were decreased in patients with ACPA-positive RA. According to multivariate models, ACPA status and sex were both independently associated with reduced biomechanical properties of bone in patients with RA (=.007 and P <.001, respectively).

Read on: Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

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