Rheumatoid arthritis can also affect the strength of bones.
Bone strength is significantly reduced among men and women with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and is associated with the development of osteoporotic fractures, according to the results of a microfinite element analysis published in the Annals of the Rheumatic Diseases.
Investigators from the University of Erlangen-Nuremberg in Germany performed microfinite element analysis to measure failure load and bone stiffness based on computed tomography data from patients with ACPA-positive RA, patients with ACPA-negative RA, and healthy control participants. Total, trabecular, and cortical bone densities, along with microstructural parameters of bone, were also analyzed.
A total of 276 participants were evaluated. Failure load and stiffness of bone were both significantly decreased in patients with ACPA-positive RA (P <.001), but not in those with ACPA-negative RA, compared with healthy control participants. Lower bone strength affected both men and women with ACPA-positive RA and was linked to longer disease duration and was significantly associated with the occurrence of osteoporotic fractures (stiffness of bone, P =.020; failure load, P =.012).
Impaired bone strength was linked to altered bone density and microstructural parameters, both of which were decreased in patients with ACPA-positive RA. According to multivariate models, ACPA status and sex were both independently associated with reduced biomechanical properties of bone in patients with RA (P =.007 and P <.001, respectively).
|Read on: Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis|
The health and medical information on our website is not intended to take the place of advice or treatment from health care professionals. It is also not intended to substitute for the users’ relationships with their own health care/pharmaceutical providers.