Cancer cells destroyed with two antipsychotic drugs

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Cancer cells destroyed with two antipsychotic drugs

Researchers are looking at some mental health medications that may destroy cancer cells in cell cultures and rodents.

Some cancers survive on high cholesterol levels. New research uses antipsychotic drugs to “starve” these cancer cells of cholesterol.

Some studies have shown that certain malignancies depend on cholesterol to survive, and that high serum cholesterol levels can predict the risk of cancer.

Moreover, a drug compound called leelaminehas been shown in recent studies to delay tumor growth in melanoma, which is a dangerous form of skin cancer.

Based on this research, scientists at the Pennsylvania State (Penn State) University Cancer Institute in Hershey — led by Omer Kuzu, a postdoctoral fellow in pharmacology — set out to stop the movement of cholesterol within treatment-resistant cancer cells.

To do so, they turned to a class of drugs called functional inhibitors of acid sphingomyelinase (FIASMAs). Specifically, they tested 42 FIASMAs that were either antipsychotics or antidepressants and compared their effects with those of leelamine.

Read on: Cancer cells destroyed with two antipsychotic drugs

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