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Cognitive Reserve Protects Against Depression in Multiple Sclerosis

Depression is a concern in multiple sclerosis.

Greater cognitive reserve protects against depression in patients with multiple sclerosis (MS), according to findings published in the Archives of Clinical Neuropsychology.

Researchers analyzed cross-sectional data of 54 patients (16 men and 38 women) with MS for cognitive, emotional, and social factors. This population had an average age of 52.6 years, mean disease duration of 16 years, and 16 participants were categorized as clinically depressed. Intelligence was evaluated through measures such as number of years of education, crystallized intelligence using the Shipley Institute of Living Scale, and cognitive healthy lifestyle factors using the Cognitive Health Questionnaire. Investigators calculated fixed cognitive reserve using years of education and the vocabulary score from the Shipley Institute of Living Scale. They also calculated malleable cognitive reserve using scores from the Cognitive Health Questionnaire. Finally, they evaluated disability using a modified self-reported Expanded Disability Status Scale and depression using the Beck Depression Inventory-Fast Screen.

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