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Diabetes Drugs May Slow Disease Activity in Multiple Sclerosis

Metformin medication could help in cases of both multiple sclerosis and metabolic syndrome.

Treatment with metformin and/or pioglitazone may have anti-inflammatory effects in patients with both multiple sclerosis (MS) and metabolic syndrome, study data indicate.

Laura Negrotto, MD, of the Institute for Neurological Research Dr Raúl Carrea in Buenos Aires, Argentina, and colleagues tested the effects of metformin and pioglitazone in 50 patients with MS who were also diagnosed with metabolic syndrome. Treatment effects were measured through MRI and serum leptin and adiponectin levels, as well as T-cell number and function.

Metabolic syndrome and the environmental factors that contribute to it have previously been linked to several autoimmune diseases. Identification of these factors is very important in order to address obstacles in the treatment and prevention of MS, wrote Aiden Haghikia, MD, and Ralf Gold, MD, in an accompanying editorial.

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