Colorectal cancer: Treatment looks set for human clinical trials
June 6, 2018
Past, Present and Possible Future Directions of MS Research Topic of Educational Talk
June 7, 2018
Show all

Diagnostic Biomarkers of Neurodegeneration in Multiple Sclerosis

Researchers are exploring better ways to diagnose multiple sclerosis.

A cross-sectional study examining the diagnostic power of neurodegeneration biomarkers in multiple sclerosis has identified 2 such biomarkers. Both neurofilament light chain levels and intrathecal immunoglobin G production may aid in characterizing the disease course. This study was published in PLoS One.

There were 271 participants in the study, all of whom showed symptoms of the onset of multiple sclerosis after diagnostic examination. These subjects were compared with 23 persons with progressive multiple sclerosis and 51 healthy controls. Researchers then classified participants into 4 different groups: those with early relapsing remitting multiple sclerosis (early RRMS; n=93) or clinically isolated syndrome (n=4); those with RRMS whose disease had presented for ≥ 2 years (established RRMS; n=39); those who displayed symptoms of multiple sclerosis but not the disease (symptomatic controls; n=89; and those with diseases other than multiple sclerosis (n=46).

The only biomarkers of neurodegeneration with significant diagnostic power were intrathecal production of immunoglobin G and an increased level of cerebral spinal fluid neurofilament light chain (median 670 ng/L; interquartile range 400 to 2110). Other biomarkers linked with progressive disease were thin layers of retinal nerve fiber, increased cerebral spinal fluid glial fibrillary acidic protein levels, and low brain parenchymal fractions. However, these indicators were not associated with other phenotypes. Thin layers of retinal nerve fiber and low brain parenchymal fractions also correlated with a longer duration of disease.

Read on: Diagnostic Biomarkers of Neurodegeneration in Multiple Sclerosis

The health and medical information on our website is not intended to take the place of advice or treatment from health care professionals. It is also not intended to substitute for the users’ relationships with their own health care/pharmaceutical providers.

Comments are closed.