HIV & AIDS Information :: AbbVie combination cures 95% of genotype 3 hepatitis C

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HIV & AIDS Information :: AbbVie combination cures 95% of genotype 3 hepatitis C

A medication combination can successfully treat genotype 3 hepatitis C infection.

AbbVie’s pangenotypic direct-acting antiviral combination of two drugs cured 95% of people with early-stage genotype 3 hepatitis C virus (HCV), the hardest genotype to treat, according to results of the ENDURANCE-3 trial presented at the International Liver Congress in Amsterdam on Friday.

The AbbVie second-generation direct-acting antiviral combination consists of a protease inhibitor and an NS5A inhibitor. Glecaprevir is an HCV NS3/4A protease inhibitor active against all genotypes of hepatitis C. Pibrentasvir is an NS5A inhibitor also active against all genotypes of hepatitis C.

A pangenotypic combination should be similarly effective against all genotypes of hepatitis C. To date, direct-acting antiviral combinations have tended to show somewhat lower efficacy in people with genotype 3, especially the hardest to treat – those with cirrhosis and those with previous experience of treatment.

The ENDURANCE-3 study was designed to test the combination of glecaprevir and pibrentasvir in people with genotype 3 infection without cirrhosis. This is the population that liver specialists can expect to see more of in their clinics as genotype 3 patients with cirrhosis are prioritised for treatment and cured, said Professor Graham Foster of Queen Mary University, London.

Genotype 3 is especially prevalent in South Asia and in South Asian populations in the United Kingdom, but these patients tend to have more advanced disease. Genotype 3 is also found in people who inject drugs, and most recent infections in Europe and North America occur in people who inject drugs.

“Genotype 3 is spreading in the US among young injectors, especially young men. For every patient that we treat and cure, that’s ten of his friends who don’t get infected,” said Prof. Foster.

Read full article: HIV & AIDS Information :: AbbVie combination cures 95% of genotype 3 hepatitis C

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