People who are infected with HIV might have a decreased risk of developing multiple sclerosis (MS).
Recently, researchers had discovered that HIV infection might decrease the risk of developing multiple sclerosis (MS).
This finding had opened the debate about the possible explanations of why.
MS is generally classified as a CD4+ Th1/Th17-mediated inflammatory disease, but recent studies have shown an important role of both CD8+ and CD19+ B cells in the pathogenesis of the disease.
And, the way HIV works is that it can infect CD4+ T cells, macrophages, and microglial cells, inducing a dysfunction of the acquired immune response.
As such, Tatiana Koudriavtseva, MD, Regina Elena National Cancer Institute, Rome, Italy, and colleagues sought to analyze the number of circulating CD3+, CD4+, CD8+, and CD19+ lymphocytes in a cohort of RRMS patients in a group of antiretroviral (ART)-treated HIV patients and compare them with a healthy control group.
Using flow cytometry, the team assessed the number of circulating CD3+, CD4+, CD8+, and CD19+ lymphocytes of 46 RRMS patients – 23 were in relapse and 23 were in remission, and 40 ART-treated HIV patients.
Read Full Article: HIV and Lower Risk of Multiple Sclerosis: There is a Connection