Read about a study suggesting that human mesenchymal stem cells (hMSCs) may be used as a therapy to treat inflammatory diseases like MS.
Human mesenchymal stem cells (hMSCs), the type of stem cells present in many tissues of adults, may be manipulated to fight inflammation and used as a cell therapy to treat inflammatory diseases like multiple sclerosis (MS), a study reports.
In the future, researchers plan to use animal models to see if the capacity of these cells to combat inflammation can be exploited to treat MS-like disease.
The study “Commitment to Aerobic Glycolysis Sustains Immunosuppression of Human Mesenchymal Stem Cells” was published in the journal Stem Cells Translational Medicine.
The research, led by a team at the Florida A&M University-Florida State University (FAMU-FSU), College of Engineering, found that hMSCs in adults can be manipulated to work in an energy-producing mode that promotes the resolution of inflammation during response to tissue injury.
hMSCs have gained extensive interest as an “off-the-shelf” potential cell therapy in the field of regenerative medicine. These type of stem cells are known for their ease of harvesting from adult donors (e.g. blood, bone, and fat tissue), and their capacity to regenerate several tissue types.
More recently, it was proposed that the tissue repair properties of hMSCs rely on their ability to modulate immune responses and help resolve inflammation at the injured site. For this to happen, hMSCs need to adapt to the local microenvironment, including changing the way they use the available nutrients to produce their energy.
Scientists found that under inflammatory conditions, these cells use sugar (glucose) alone together with oxygen to produce their energy, a type of metabolism referred to as aerobic glycolysis. Importantly, when they use this type of energy-producing mechanism, their ability to inhibit inflammation gets enhanced.
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