What do a terminal brain disease and a painful autoimmune condition have in common?More than we thought.Scientists from the University of California San Diego (UCSD) School of Medicine and the Icahn School of Medicine at Mount Sinai in New York have discovered an apparent epigenetic overlap between the origins of Huntington’s disease and that of rheumatoid arthritis (RA).The researchers shared their findings last month in the journal, Nature Communications.Using cutting-edge analytical tools, the scientists analyzed the epigenomic landscape of RA and compared it to other conditions.

They discovered the overlap between the origins of Huntington’s and the origins of RA. They proclaimed it a potential common cause.

Or at least a partial commonality.

Huntington’s is a fatal and incurable brain disease with a wide and disabling array of neurological and functional implications and deficits.

Rheumatoid arthritis is a painful and chronic inflammatory autoimmune disease that primarily affects the joints as well as some organs.

Other than depression and muscle stiffness, there are virtually no known similarities between the diseases.

Until now.

While the diseases themselves may not be similar — Huntington’s is far more disabling than RA — researchers say their origins are, in fact, epigenetically linked.

This may be where the common ground ends for these two illnesses, but it was noteworthy enough for researchers to address the overlap.

“We did not expect to find an overlap between rheumatoid arthritis and Huntington’s disease, but discovering the unexpected was the reason that we developed this technology,” Dr. Gary Firestein, a senior study investigator and dean and associate vice chancellor of translational medicine at the UCSD School of Medicine, said in a statement. “Now that we have uncovered this connection, we hope that it opens a door for treatment options for people living with either disease.”