Whether your colon cancer started on the left side or the ride side could affect your chances of survival.
People with cancer that starts on the left side of their colon live significantly longer than those with right-side tumors, according to a new study that provides insights into how best to match drugs to patients with advanced disease.
The retrospective analysis, released Wednesday, involved a federally funded clinical trial with more than 1,100 colon-cancer patients. Overall, it found that those with left-side tumors survived for a median of 33.3 months, while those with right-side tumors survived for 19.4 months.
Lead author Alan Venook, a professor of medicine at the University of California at San Francisco, said previous studies had suggested tumor location played a role in patients’ survival, but the effect shown by the new study was greater than he expected.
The data also turned up a striking difference in drug efficacy depending on the location of the tumors. Two therapies were used in the trial, in combination with chemotherapy, to see whether one worked better than the other. The answer was no, based on initial results.
But when the data was evaluated based on a tumor’s location, things changed. Avastin was associated with longer survival times in cases of right-side tumors, while Erbitux was linked to longer survival with left-side malignancies.
|Read Full Article: If you get colon cancer, your prognosis depends partly on where it started – The Washington Post|