Reprogramming liver cells could help those with diabetes.
It is now possible to reprogram cells from the liver into the precursor cells that give rise to the pancreas by altering the activity of a single gene. A team of researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) has now accomplished this feat in mice. Their results should make it feasible to help diabetic patients through cell therapy.
In patients suffering from type I diabetes, their immune system turns against their own bodies and destroys a type of pancreatic cell called islet cells. Without these cells, the pancreas is unable to produce the hormone insulin and blood glucose rises, which leads to diabetic disease. At that point, such patients need to inject insulin for the rest of their lives.
A way to provide a lasting help to the afflicted may be to grow new pancreatic cells outside of the body. MDC group leader and researcher Dr. Francesca has been pursuing the idea of reprogramming liver cells to become pancreatic cells. Dr. Spagnoli’s team has now succeeded in thrusting liver cells into an “identity crisis” — in other words, to reprogram them to take on a less specialized state — and then stimulate their development into cells with pancreatic properties.
|Read Full Article: Inducing an identity crisis in liver cells may help diabetics: First successful reprogramming of liver cells to pancreas progenitor cells based on a single factor — ScienceDaily|