Liver cancer may be diagnosed from altered sugar metabolism

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Liver cancer may be diagnosed from altered sugar metabolism

Cancer cells in the liver appear to have a lower metabolism of sugar than other cells, which could be a way to diagnose cancer.

Altered gene expression that causes cancerous cells to metabolize fructose differently from healthy cells could be a significant new biomarker for diagnosing liver cancer.
So concludes a study led by the University of Texas MD Anderson Cancer Center in Houston and published in the journal Nature Cell Biology.

The study reveals that a gene called KHK (ketohexokinase or fructokinase) is expressed differently in cancerous versus normal liver tissue.

Senior author Zhimin Lu, professor of neuro-oncology at MD Anderson, says:

“Normal liver cells catalyze both glucose and fructose for energy, amino acid and lipid production. However, we found that liver tumors stopped using fructose. Thus, monitoring fructose metabolism could potentially be used for liver cancer diagnosis.”

Read Full Article: Liver cancer may be diagnosed from altered sugar metabolism – Medical News Today

Read Full Article: Liver cancer may be diagnosed from altered sugar metabolism – Medical News Today

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