Liver Disease More Prevalent in Patients with Crohn’s Disease

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Liver Disease More Prevalent in Patients with Crohn’s Disease

An analysis of more than 62,000,000 found that prevalence rates of nonalcoholic fatty liver disease were 3 times higher in patients with Crohn’s disease.

A study from investigators at the Cleveland Clinic has found that patients with Crohn’s disease (CD) may be at an increased risk of nonalcoholic fatty liver disease (NALFD), nonalcoholic steatohepatitis (NASH) and nonalcoholic cirrhosis (NC).

In a study of more than 62,000,000 patients, investigators found that prevalence rates of NAFLD, NASH, and NC among patients with CD were 3 times higher than in the general population. After noting it within their own practices, investigators sought to determine whether or not patients with CD were at an increased risk of chronic liver disease.

“It’s certainly an increasingly finding in my practice in caring for patients with inflammatory bowel disease (IBD), including Crohn’s disease, and there’s currently an epidemic of fatty liver disease in the western population,” explained Benjamin Click, MD, study author and associate staff gastroenterologist at the Cleveland Clinic in an interview with MD Magazine. “So, it’s important to understand if IBD patients are at any additional or different risk for liver disease.”

Investigators used electronic health record data, obtained through a commercial database, from 26 major US heal care systems to identify patients with a diagnosis of Crohn’s disease from 1999 to 2018.  Patients were identified with a Systemized Nomenclature of Medicine — Clinical Terms diagnosis of CD. Investigators used logistic regression of demographic and metabolic comorbidities to identify potential risk factors. Additionally, prevalence rates of first ever diagnosis of NAFLD, NASH, and NC after 30 days of CD diagnosis with the general population from the commercial database.

Read on: Liver Disease More Prevalent in Patients with Crohn's Disease

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