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MS Patients Report Lesser Fatigue After aHSCT in Canadian Study

Read about a study that found 23 relapsing-remitting MS patients reported lesser fatigue over three years following hematopoietic stem cell transplant.

A small group of multiple sclerosis (MS) patients with aggressive disease, who were treated with hematopoietic stem cell transplant in a clinical trial, reported a drop in their fatigue levels that researchers suggested was likely due to lesser inflammation.

The study, “Autologous hematopoietic stem cell transplantation improves fatigue in multiple sclerosis,”  was published in the Multiple Sclerosis Journal.

Immunoablation — the wiping out of the immune system — with high-dose chemotherapy, followed by its rescue with autologous hematopoietic stem cell transplantation (aHSCT) has proven to be an effective way of treating inflammatory activity in the central nervous system of MS patients. However, the treatment’s effect on fatigue, a common MS symptom affecting as many as 90% of all patients, has not been examined.

Researchers in Canada aimed to assess fatigue in MS patients before and after aHSCT treatment.

Their study looked at data from a Phase 2 clinical trial (NCT01099930) in which MS patients — with ongoing relapses and progression despite the use of disease-modifying therapies — went through this aHSCT procedure. Patients were followed regularly afterward, and every six months for three years completed a self-reported fatigue questionnaire looking at seven specific measures.

The Multiple Sclerosis Council for Clinical Practice Guidelines recommend the use of a scale called the modified Fatigue Impact Scale (mFIS) for assessing the degree of fatigue experienced by MS patients. mFIS is composed of 21 questions and is a modified form of the more elaborate 40-question FIS.

In total, the study analyzed data from 23 patient, resulting in 148 FIS measurements over the three years.

At baseline, most patients (20) had high mFIS scores that ranged between 30 and 46.5, with a median score of 36. The higher the mFIS score, the worst is the fatigue level.

At a six-month post-treatment follow-up, mFIS score ranges dropped to a median 25.5, declining further to a median score of 23 at the study’s end. This represented a significant drop in fatigue measures with a 36% reduction in mFIS score.

Four patients had a reported 100% reduction in their fatigue scores at three years post-aHSCT.

Read on: MS Patients Report Lesser Fatigue After aHSCT in Canadian Study

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