Neural stem cells derived from a patient’s own skin might repair multiple sclerosis damage in the future.
These “induced neural stem cells” (iNSCs) were transplanted into the rodents’ cerebrospinal fluid.
Lead study author Dr. Stefano Pluchino, of the Department of Clinical Neurosciences at the University of Cambridge, and team believe that their strategy could offer a promising treatment for MS and other neurological diseases.
The researchers recently reported their findings in the journal Cell Stem Cell.
MS is a progressive neurological disease that is estimated to affect more than 2.3 million peopleacross the globe.
While the precise causes of MS remain unclear, “an abnormal immune system response” is thought to be involved. Such a response leads to inflammation in the CNS, which causes the destruction of myelin, or the fatty substance that protects nerve fibers.
As a result, the nerve fibers become damaged. This disrupts neuronal signaling and triggers the neurological symptoms of MS, including tingling in the face or extremities and problems with movement, balance, and coordination.
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