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Need to Know: High-dose Biotin Protocol for Multiple Sclerosis

Columnist Tamara Sellman examines findings from research into the use of high-dose biotin to treat MS-related disability.

What is the high-dose biotin protocol?

Recent research points to the use of a vitamin supplement, biotin, to treat primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS).

A recent study discussed at last fall’s European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) event in Berlin, while limited in size and focus, may spark further research into what could be an inexpensive and safe approach to halting the disabling effects of MS.

What is biotin?

Biotin, or vitamin B7, belongs to the group of B vitamins. It’s water-soluble, which helps to metabolize substances including fatty acids and glucose, and convert food into caloric energy.

It’s considered a safe supplement, as the body doesn’t store biotin and excess biotin is excreted. The recommended daily dose is 30 micrograms (mcg) for adults and pregnant women, and 35 mcg for breastfeeding women.

People who drink alcohol in excess may need to supplement their biotin levels.

Don’t want to take a supplement? You can find biotin in foods such as yeast, egg yolks, broccoli, sweet potatoes, spinach, milk, bananas, nuts, grains, and liver.

How might biotin help with MS?

According to the findings of a recent study discussed in Neurology Advisor, high doses of biotin reversed MS-related disability in 13 percent of PPMS patients who used the protocol.

This form of high-dose, pharmaceutical-grade biotin, MD1003, is manufactured under the name Qizenday by medDay Pharmaceuticals.

This protocol is currently under Phase 3 investigation (with a completion date expected in September 2019) for application in progressive patients (NCT02936037). MS specialists in France are currently prescribing it to their progressive patients.

Other research suggests that high doses of MD1003 — 300 mg (100 mg taken three times daily) — may assist the brain with remyelination.

Read on: Need to Know: High-dose Biotin Protocol for Multiple Sclerosis

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