10 Men on Why Speaking Out About Men’s Mental Health Is So Important
May 25, 2018
Merck’s Keytruda helps lung cancer patients live longer in trial
May 25, 2018
Show all

Risk of Developing Multiple Sclerosis After HPV Vaccination

Is there a the link between HPV vaccination and multiple sclerosis?

There is no significant association between the human papillomavirus (HPV) vaccination and multiple sclerosis, despite concerns over its propensity to cause the development of central nervous system autoimmune disorders, according to findings in a systematic literature review published in Human Vaccines & Immunotherapeutics.

The literature review identified relevant articles from a search performed in 5 different search engines: ClinicalTrials.gov, Google Scholar, ISI Web of Knowledge, Medline, and Scopus. From this search, 15 different publications met established criteria during evaluation to be utilized for the qualitative synthesis. Of these publications, 1 pooled randomized clinical trial analysis, 5 were observational studies, and 9 were reviews. Of the 5 observational studies, 2 were case-control studies and 3 were cohort studies. Of the reviews, 2 were systematic and 7 were narrative.

The review of the cohort studies revealed that the relative risk for multiple sclerosis onset ranged from 1.54 (95% CI, 0.04-8.59) to 1.37 (95% CI, 0.74-3.20). In case-control studies, for the group exposed to the HPV vaccination, the odds ratio ranged from 0.3 (95% CI, 0.1- 0.9) to 1.60 (95% CI, 0.79-3.25). Neither of these results is significant, indicating that there is not a strong connection between multiple sclerosis onset and the HPV vaccination.

This literature review was conducted in response to the controversial nature of the correlation between the HPV vaccination and the development of central nervous system autoimmune disorders. Although the review shows no significant association between the vaccine and multiple sclerosis, the research is limited and cannot be generalized across all instances of central nervous system autoimmune disorders.

Read on: Risk of Developing Multiple Sclerosis After HPV Vaccination

The health and medical information on our website is not intended to take the place of advice or treatment from health care professionals. It is also not intended to substitute for the users’ relationships with their own health care/pharmaceutical providers.

Comments are closed.