Read about a study showing that the rate of kidney deterioration has a result of bladder dysfunction due to MS is low.
The rate of kidney deterioration as a result of bladder dysfunction due to multiple sclerosis (MS) is low, affecting only 3 percent of the patients, a single tertiary center study shows.
However, kidney deterioration is a slow process and detected only after 60 months of follow-up, highlighting the need for continued monitoring of MS patients who have lower urinary tract symptoms.
The study “Assessment of renal deterioration and associated risk factors in patients with multiple sclerosis” was published in the journal Urology.
MS patients often experience lower urinary tract symptoms, or LUTS, with up to 75 percent of patients reporting moderate-to-severe symptoms.
LUTS is a term that describes problems in holding or in frequency to urinate, urge incontinence, and nocturia (the need to wake at night one or more times to urinate), among others. Individuals with LUTS are at higher risk of their kidney function deteriorating.
Previous studies have identified MS disease duration and Expanded Disability Status Scale score (EDSS) — a method of quantifying disability in MS — as predictors of kidney deterioration.
In this study, a team of researchers at University of Texas Southwestern Medical Center evaluated the prognostic potential of these parameters in a group of patients with bladder dysfunction due to MS — a condition called neurogenic bladder.
They reviewed data of 660 patients followed in a tertiary center from December 1999 to September 2016.
Kidney deterioration was defined according to established criteria, namely patients who underwent at least two visits to the clinic due to LUTS, and who had more than double the normal levels of creatinine in the blood. Creatinine is a waste product filtered out of the blood into urine in the kidneys, so measuring its levels is a simple way to assess renal function.
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