Scientists find ‘chink in armour’ of aggressive childhood cancer

Hepatitis C batters a state unable to afford the cure
November 18, 2016
Bryan Bickell diagnosed with multiple sclerosis
November 18, 2016
Show all

Scientists find ‘chink in armour’ of aggressive childhood cancer

Scientists are working to better understand and combat childhood cancer.

Scientists believe they may have found a way to treat a rare but devastating cancer that kills young children often within months of their diagnosis.

There is currently no treatment for malignant rhabdoid tumours, which usually develop in the kidneys and have no symptoms in the early stages. By the time they are diagnosed, the cancer has often spread to other organs and is fatal. Most of those affected are infants and toddlers.

The mutated gene that causes the cancer is well known, but scientists have not been able to find a way to target it. However, scientists working for the Institute of Cancer Research (ICR) believe they have a made a breakthrough. They have now identified two other genes that appear to be implicated in driving the growth of the tumour, which produce proteins that can be inhibited by drugs that are already in use in other cancers or are in the development pipeline.
Prof Paul Huang, team leader of the protein networks laboratory at the ICR, says they have found “a chink in the armour” of these very aggressive tumours, using drugs that attack proteins known as kinase inhibitors.

“There are a lot of kinase drugs out there, so we don’t have to re-invent the wheel,” he said. “In many cases in drug discovery you find a new target and spend 10 to 20 years developing drugs against it.”

In this case, they hope that will not be necessary . “We have been able to re-purpose existing drugs, some of which are already approved.”

Read Full Article: Scientists find ‘chink in armour’ of aggressive childhood cancer | Science | The Guardian

Read Full Article: Scientists find ‘chink in armour’ of aggressive childhood cancer | Science | The Guardian

The health and medical information on our website is not intended to take the place of advice or treatment from health care professionals. It is also not intended to substitute for the users’ relationships with their own health care/pharmaceutical providers.

Comments are closed.