There is a genetic connection underlying Crohn’s disease.
Researchers say they’ve come closer to pinpointing genes linked with inflammatory bowel diseases such as Crohn’s and ulcerative colitis.
For the study, the investigators examined the genomes of nearly 68,000 people. Of the regions of the genome associated with inflammatory bowel disease (IBD), 18 could be traced to a single genetic variant with more than 95 percent certainty.
“We have taken the biggest ever data set for IBD and applied careful statistics to narrow down to the individual genetic variants involved,” said study co-author Dr. Jeffrey Barrett, from the Wellcome Trust Sanger Institute in the United Kingdom.
“Now we have a clearer picture of which genes do and do not play a role in the disease. We are zooming in on the genetic culprits of IBD,” he said in an institute news release.
The findings could lead to improved effectiveness of current treatments for IBD, as well as the discovery of new drug targets, the study authors said.
In diseases such as Crohn’s and ulcerative colitis, the body’s immune system attacks parts of the digestive tract. Symptoms can include abdominal pain, cramping, diarrhea, rectal bleeding and extreme fatigue. The causes of the disease are unclear, and there is currently no cure.
Read full article: Scientists Spot Genes Behind Crohn’s, Ulcerative Colitis
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