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Study uncovers markers for severe form of multiple sclerosis

Learn about markers for multiple sclerosis.

Scientists have uncovered two closely related cytokines — molecules involved in cell communication and movement — that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease. The findings, authored by researchers at Yale University, Oregon Health & Science University, and the University of California point the way toward developing a novel treatment to prevent progressive forms of the disease.

The research was published today in the Proceedings of the National Academy of Sciences.

Researchers identified a cytokine, called macrophage migration inhibitory factor (MIF), along with its related protein, D-dopachrome tautomerase (D-DT), which are associated with progressive MS. These cytokines worsen the disease by increasing inflammation within the central nervous system. The researchers also linked enhanced expression of MIF with a gene variant that occurred more frequently in MS patients with progressive disease — particularly in men.

Read full article: Study uncovers markers for severe form of multiple sclerosis | YaleNews

Read Full Article: Study uncovers markers for severe form of multiple sclerosis | YaleNews

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