The interaction of two genes appears to significantly increase the risk of multiple sclerosis.
The research, which gave scientists insight into the processes that cause MS, also suggested that another mutation increased the effects of a known MS risk gene.
The study, “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk,” was published in the journal Cell.
“Our study identifies an interaction with a known MS risk gene to unlock a new MS candidate gene, and in doing so, opens up a novel mechanism that is associated with the risk of multiple sclerosis and other autoimmune diseases,” Simon Gregory, one of two co-senior authors of the study, said in a press release.
Gregory is director of Genomics and Epigenetics at the Duke Molecular Physiology Institute at Duke University Medical Center.
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